Leaders Barcelona and Real Madrid were held to draws while Sevilla made up ground on the top two and Alaves slipped after a promising start. Here are five talking points from the weekend's La Liga action.
Barcelona coach Ronald Koeman has joined other managers in lashing out at the packed European football calendar after deciding to rest Lionel Messi for Tuesday's Champions League trip to Dynamo Kyiv.
Real Madrid ended their long wait for a La Liga victory by beating Real Valladolid 2-0 on Saturday with two late goals in interim coach Santiago Solari's first home game in charge of the struggling European champions.
Serge Gnabry scored twice as Bayern Munich beat Chelsea 3-0, while Antoine Griezmann's second-half equaliser handed Barcelona a vital away goal and earned them a 1-1 draw at Napoli in their Champions League last 16, first leg on Tuesday.
The 28-year-old did not reveal where he would be playing next but widespread reports in the Spanish media said he would be joining Barcelona.
Atletico Madrid won the La Liga title for the first time since 2014
The draw means second-placed Atletico Madrid could close the 12-point gap with Barcelona, who are on 74 points, if they beat Celta Vigo later on Saturday.
Luis Suarez had the Barcelona fans chanting his name after he set up Lionel Messi to score the opening goal in their King's Cup semis.
Xavi brought his glittering Barcelona career to a fitting and emotional end when he hoisted aloft the European Cup following a 3-1 victory over Juventus in the Champions League final.
IMAGES from the La Liga matches played on Tuesday
The event played in one location over seven days in November could start next year, pending approval by the ITF Board.
News of all that's transpired on and off the football field
Holders Barcelona cruised into the King's Cup quarter-finals when a side missing several regulars beat city rivals Espanyol 2-0, with Munir El Haddadi netting both goals in a thumping 6-1 aggregate success on Wednesday.
Barcelona's outlay of 20 million euros ($22 million) on Jeremy Mathieu last July prompted plenty of criticism but the France centre back has been worth his weight in gold in the La Liga leaders' last two outings.
Cesc Fabregas struck the winner as an experimental Spain side came from behind to beat Costa Rica 2-1.
India caused a stir in Zagreb where veteran duo Leander Paes and Rohan Bopanna edged Mate Pavic and Franko Skugor in Saturday's doubles to keep alive the tie but Marin Cilic quickly doused Indian hopes with a 6-0, 6-1 win over Sumit Nagal.
Manchester City cannot afford another defeat on Tuesday at home to Barcelona, who thumped them 4-0 two weeks ago, having taken just one point from their last two Champions League Group C matches.
Real Madrid coach Zinedine Zidane is under pressure to break up his misfiring attacking trio of Cristiano Ronaldo, Karim Benzema and Gareth Bale when he takes the La Liga leaders to Alaves on Saturday.
A summary of Wednesday night's action in the UEFA Champions League.
An insatiable Lionel Messi hit a hat-trick as Barcelona hammered Espanyol 5-0 in a local derby on Saturday to make it three wins from three and take full advantage after Liga champions Real Madrid were held to a 1-1 draw at home to Levante.
Real Madrid and Atletico each slipped 10 points behind La Liga leaders Barcelona after an intense Madrid derby finished goalless and the Catalans picked up an 11th victory in 12 games by winning 3-0 at Leganes.
The South American trio of Lionel Messi, Neymar and Luis Suarez reached a scorching 108 goals for the season following the La Liga leaders' 8-0 destruction of Cordoba on Saturday but the team's defence is yet to dispel doubts
Barcelona's poor run away to Real Sociedad continued when the champions were held to a 1-1 draw at Anoeta on Sunday and slipped six points behind La Liga leaders Real Madrid before next week's 'Clasico' against their arch rivals.
News of all that's transpired on and off the football field
Djokovic helped Serbia to a 3-0 victory over Japan in their Group A opener on Wednesday at La Caja Magica where a revamped Davis Cup climax is being contested by 18 nations over seven days.
Messi, who has struggled for form in recent weeks due to a niggling injury, looked on a mission to grab the winner and after twice coming close he completed his treble to put Barca ahead in the 85th minute, reacting quickly to a poor Sevilla clearance to dink the ball over goalkeeper Tomas Vaclik.
Underlying tensions mean Luis Enrique will not be remembered with the same reverence as Pep Guardiola, even though he has delivered a similar trophy haul.
Images from the UEFA Champions League quarter-final first leg matches played on Wednesday
Zinedine Zidane has said his side are in a delicate situation as they prepare to host arch-rivals Barcelona in a La Liga title showdown on Sunday
Barcelona put pressure on La Liga leaders Real Madrid by picking up their first win in four games as two second-half strikes from Lionel Messi and one from Luis Suarez secured a 3-0 win at struggling Osasuna on Saturday.
Lionel Messi-inspired Barcelona overwhelmed Manchester City as Ivan Rakitic's strike secured a 1-0 win.
Lionel Messi scored a 50th freekick goal for Barcelona as he led his side to a quick-fire comeback to win 3-2 at Valencia on Sunday and keep the pressure on La Liga title rivals Atletico Madrid and Real Madrid.
Barcelona battled back from a goal down and scored twice in the second half to overcome hosts Borussia Moenchengladbach 2-1 in their Champions League Group C match on Wednesday despite the absence of the injured Lionel Messi.
When Griezmann fired Atletico to victory over Olympique de Marseille in the Europa League final in May it was widely viewed as his last stand for Diego Simeone's side before a move to Barca but they successfully convinced the Frenchman to stay.
Spain coach Luis Enrique promised evolution rather than revolution when he took charge of the national side following their disastrous World Cup campaign this year when they were eliminated in the round of 16.
Barcelona must appreciate matching the club's record of nine wins and a draw in their first 10 games of a Liga campaign, especially after Real Madrid's defeat at Girona, coach Ernesto Valverde told a news conference on Monday.
Aritz Aduriz's second half hat-trick sent Barcelona spinning to a shock 4-0 defeat at Athletic Bilbao in the first leg of the Spanish Super Cup on Friday.
Cristiano Ronaldo scored his 400th goal for Real Madrid as Zinedine Zidane's side closed in on a first La Liga title since 2012, easing to a 4-1 win over Sevilla on Sunday while Neymar hit a hat-trick for Barcelona, who thrashed Las Palmas 4-1.
Real Madrid coach Zinedine Zidane said he was disappointed that he was only asked about the referee's decisions after his side earned a 2-1 victory at Real Sociedad on Sunday to climb above Barcelona and top La Liga.
Luis Suarez scored a hat-trick and Lionel Messi bagged a brace as Barcelona thrashed bottom side Cordoba 8-0 on Saturday to move a step closer to their fifth La Liga title in seven years.